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Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
| Title: | Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae. |
 115 views 21 downloads |
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| Name(s): |
Wright, Amy E., creator Botelho, J. C., creator Guzman, Esther A., creator Harmody, Dedra K., creator Linley, P. A., creator McCarthy, Peter J., creator Pitts, Tara P., creator Pomponi, Shirley A., creator Reed, John K., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2007 | |
| Publisher: | The American Chemical Society and American Society of Pharmacognosy | |
| Extent: | 6 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3333011 (digitool), FADT3333011 (IID), fau:6208 (fedora), 10.1021/np060597h (doi) | |
| Note(s): |
A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 µg/mL. This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np060597h. This article may be cited as: Wright, A. E., Botelho, J. C., Guzmán, E., Harmody, D., Linley, P., McCarthy, P. J., Pitts, T. P., Pomponi, S. A., & Reed, J. K. (2007). Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae. Journal of Natural Products, 70(3), 412-416. doi:10.1021/np060597h Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1649. |
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| Subject(s): |
Sponges Macrolides Marine natural products |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3333011 | |
| Links: | http://dx.doi.org/10.1021/np060597h | |
| Restrictions on Access: | ©2007 The American Chemical Society and American Society of Pharmacognosy | |
| Host Institution: | FAU |
