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Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis
| Title: | Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis. |
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| Name(s): |
Gunasekera, Sarath P., creator Cranick, S., creator Longley, Ross E., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1989 | |
| Publisher: | The American Chemical Society and American Society of Pharmacognosy | |
| Extent: | 6 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3332960 (digitool), FADT3332960 (IID), fau:6182 (fedora), 10.1021/np50064a015 (doi) | |
| Note(s): |
Two immunosuppressive compounds, 4 α-methyl-5 α-cholest-8-en-3 β-ol and 4, 5-dibromo-2-pyrrolic acid [2] were isolated from a deep water marine sponge, Agelas flabelliformis. Their structures were determined by comparison of their spectral data with those of samples isolated from other organisms. Both compounds were highly active in suppression of the response of murine splenocytes in the two-way mixed lymphocyte reaction (MLR) with little to no demonstrable cytotoxicity at lower doses. In addition, 4, 5-dibromo-2-pyrrolic acid suppressed the proliferative response of splenocytes to suboptimal concentrations of the mitogen, concanavalin A (Con A). These results describe for the first time compounds isolated from the marine sponge A. flabelliformis that possess potent in vitro immunosuppressive activity. This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50064a015. This article may be cited as: Gunasekera, S. P., Cranick, S., & Longley, R. E. (1989). Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis. Journal of Natural Products, 52(4) 757-761. doi:10.1021/np50064a015 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #710. |
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| Subject(s): |
Sponges Immunosuppressive agents Marine metabolites |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3332960 | |
| Links: | http://dx.doi.org/10.1021/np50064a015 | |
| Restrictions on Access: | ©1989 The American Chemical Society and American Society of Pharmacognosy | |
| Host Institution: | FAU |
