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Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity

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Date Issued:
1994
Title: Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity.
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Name(s): Koehn, F. E., creator
Longley, Ross E., creator
Sennett, Susan H., creator
Reed, John K., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1994
Publisher: American Chemical Society
Extent: 7 p.
Physical Description: pdf
Language(s): English
Identifier: 3331884 (digitool), FADT3331884 (IID), fau:6136 (fedora), 10.1021/jm00045a024 (doi)
Note(s): A series of analogs of the immunosuppressive lipopeptide microcolin A has been prepared and evaluated for in vitro activity in the human and murine two-way mixed lymphocyte reaction. The compounds tested were obtained by semisynthetic modification and chemical degradation of the natural product. The relative potencies of these analogs suggest that the hydroxyproline and 5-methyl-3-pyrrolin-2-one portion of the molecule are important for immunosuppressive activity and that other structural elements may play an ancillary role. Methanolysis of microcolin A also led to a novel immunosuppressive lactone analog.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Medicinal Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jm00045a024. This article may be cited as: Koehn, F. E., McConnell, O. J., Longley, R. E., Sennett, S. H., & Reed, J. K. (1994). Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity. Journal of Medicinal Chemistry, 37(19), 3181-3186. doi:10.1021/jm00045a024
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1050.
Subject(s): Immunosuppressive agents
Immunosuppressive agents--Mechanism of action
Immunosuppressive agents--Testing
Marine natural products
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3331884
Links: http://dx.doi.org/10.1021/jm00045a024
Restrictions on Access: ©1994 American Chemical Society
Owner Institution: FAU