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Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata

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Date Issued:
2013
Summary:
Sponges are an important source of bioactive marine natural products, or secondary metabolites. The common Caribbean reef sponge, Axinella corrugata, produces an antitumor and antibacterial chemical, stevensine. This study determined whether environmental stressors, such as elevated temperature and exposure to Amphibalanus amphitrite larvae, affect the production of stevensine by A.corrugata and if the stressors caused A.corrugata to exhibit differential gene expression. Temperature stress resulted in no significant change in the production of stevensine; only two genes were significantly differentially expressed, including hsp70. Larval stressed resulted in increased production of stevensine and significant differential gene expression (more than seventy genes). This study suggests that A.corrugata may be resilient to elevations in temperature and that one of stevensine's roles in nature is as an antifoulant.
Title: Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata.
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Name(s): Grima, Jennifer.
Charles E. Schmidt College of Science
Department of Biological Sciences
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Issued: 2013
Publisher: Florida Atlantic University
Physical Form: electronic
Extent: ix, 41 p. : ill. (some col.)
Language(s): English
Summary: Sponges are an important source of bioactive marine natural products, or secondary metabolites. The common Caribbean reef sponge, Axinella corrugata, produces an antitumor and antibacterial chemical, stevensine. This study determined whether environmental stressors, such as elevated temperature and exposure to Amphibalanus amphitrite larvae, affect the production of stevensine by A.corrugata and if the stressors caused A.corrugata to exhibit differential gene expression. Temperature stress resulted in no significant change in the production of stevensine; only two genes were significantly differentially expressed, including hsp70. Larval stressed resulted in increased production of stevensine and significant differential gene expression (more than seventy genes). This study suggests that A.corrugata may be resilient to elevations in temperature and that one of stevensine's roles in nature is as an antifoulant.
Identifier: 851064717 (oclc), 3360781 (digitool), FADT3360781 (IID), fau:4093 (fedora)
Note(s): by Jennifer Grima.
Thesis (M.S.)--Florida Atlantic University, 2013
Includes bibliography.
Mode of access: World Wide Web.
System requirements: Adobe Reader.
Subject(s): Axinellida
Sponges
Marine pharmacology
Adaptation (Biology)
Gene expression
Genetic regulation
Stress (Physiology)
Ecophysiology
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/3360781
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU