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Myokine Cathepsin B Expression with Exercise Training in the 3xTg-AD Murine Model of Alzheimer’s Disease

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Date Issued:
2018
Abstract/Description:
This research investigated the relationship between exercise training and cathepsin B expression in the 3xTg-AD murine model of Alzheimer’s disease. 3xTg-AD mice were assigned to control (Tg, n=10), aerobic training (Tg+AT, n=10), or resistance training (Tg+RT, n=10). RotaRod peak latency and grip strength were assessed as preand post-measurements. Skeletal muscle was collected after training and analyzed for cathepsin B protein. Tg+RT showed greater grip strength than Tg and Tg+AT at posttesting (p ≤ 0.05). Only Tg+AT showed an improvement in RotaRod peak latency (p ≤ 0.05). Gastrocnemius weight was greater in Tg+RT compared to Tg (p ≤ 0.05), and no differences were observed in cathepsin B or procathepsin B expression (p > 0.05). This data suggests that cathepsin B was not induced by either mode of exercise training, however, physical function and muscle mass were improved, therefore inclusion of both training modalities may address peripheral comorbidities in Alzheimer’s disease.
Title: Myokine Cathepsin B Expression with Exercise Training in the 3xTg-AD Murine Model of Alzheimer’s Disease.
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Name(s): Paez, Hector G., author
Khamoui, Andy V., Thesis advisor
Florida Atlantic University, Degree grantor
College of Education
Department of Exercise Science and Health Promotion
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Created: 2018
Date Issued: 2018
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 51 p.
Language(s): English
Abstract/Description: This research investigated the relationship between exercise training and cathepsin B expression in the 3xTg-AD murine model of Alzheimer’s disease. 3xTg-AD mice were assigned to control (Tg, n=10), aerobic training (Tg+AT, n=10), or resistance training (Tg+RT, n=10). RotaRod peak latency and grip strength were assessed as preand post-measurements. Skeletal muscle was collected after training and analyzed for cathepsin B protein. Tg+RT showed greater grip strength than Tg and Tg+AT at posttesting (p ≤ 0.05). Only Tg+AT showed an improvement in RotaRod peak latency (p ≤ 0.05). Gastrocnemius weight was greater in Tg+RT compared to Tg (p ≤ 0.05), and no differences were observed in cathepsin B or procathepsin B expression (p > 0.05). This data suggests that cathepsin B was not induced by either mode of exercise training, however, physical function and muscle mass were improved, therefore inclusion of both training modalities may address peripheral comorbidities in Alzheimer’s disease.
Identifier: FA00013092 (IID)
Degree granted: Thesis (M.S.)--Florida Atlantic University, 2018.
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Includes bibliography.
Subject(s): Cathepsins.
Alzheimer's disease.
Aerobic exercises.
Resistance Training.
Held by: Florida Atlantic University Libraries
Sublocation: Digital Library
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00013092
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Owner Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.