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LONG-TERM EFFECTS OF PRE-NATAL OXYCODONE EXPOSURE IN MICE

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Date Issued:
2017
Abstract/Description:
Prescription drug abuse is a rapidly emerging epidemic. One serious consequence of this abuse is increased incidence of neonatal abstinence syndrome (NAS). NAS results from a pregnant mother abusing opiates during her gestation period. The short-term effects of in utero opiate exposure on newborns are well documented, but the long-term impacts are poorly known. Our project in the Miller Lab aimed to characterize the impacts of prenatal opiate exposure on the behavior of mice. Our data indicates that mice exposed to oxycodone in utero show abnormal, impulsive-like behavior and had a lower seizure threshold compared to control mice. We can now work towards identifying possible underlying brain structural abnormalities producing this phenotype, and we are now more prepared to deal with the lifelong impact of this exposure.
Title: LONG-TERM EFFECTS OF PRE-NATAL OXYCODONE EXPOSURE IN MICE.
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Name(s): Skaf, Daniel, author
Wetterer, James K., Thesis advisor
Florida Atlantic University, Degree Grantor
Harriet L. Wilkes Honors College
Type of Resource: text
Genre: Thesis
Date Created: 2017
Date Issued: 2017
Publisher: Florida Atlantic University
Place of Publication: Jupiter, Florida
Physical Form: application/pdf
Extent: 26 p.
Language(s): English
Abstract/Description: Prescription drug abuse is a rapidly emerging epidemic. One serious consequence of this abuse is increased incidence of neonatal abstinence syndrome (NAS). NAS results from a pregnant mother abusing opiates during her gestation period. The short-term effects of in utero opiate exposure on newborns are well documented, but the long-term impacts are poorly known. Our project in the Miller Lab aimed to characterize the impacts of prenatal opiate exposure on the behavior of mice. Our data indicates that mice exposed to oxycodone in utero show abnormal, impulsive-like behavior and had a lower seizure threshold compared to control mice. We can now work towards identifying possible underlying brain structural abnormalities producing this phenotype, and we are now more prepared to deal with the lifelong impact of this exposure.
Identifier: FA00012638 (IID)
Degree granted: Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2017.
Collection: FAU Honors Theses Digital Collection
Note(s): Includes bibliography.
Held by: Florida Atlantic University Libraries
Sublocation: Digital Library
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00012638
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.

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