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Identification of longitudinals lacking (LOLA) target genes in Drosophila melanogaster

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Date Issued:
2010
Summary:
Longitudinals lacking gene (LOLA) is a transcription factor that is involved in a variety of axon guidance decisions in Drosophila melanogaster nervous system. Besides having a role as an epigenetic silencer and in the programmed cell death in Drosophila's ovary, this gene is also an example of complex transcription unit. LOLA is a transcription repressor and can generate 17 DNA - binding isoforms, through alternative splicing, each containing distinct zinc-finger proteins. This unique DNAbinding binding sequence to which LOLA-ZFP binds has been determined for four of the lola isoforms F, J, P and K. Also, bioinformatics' tool approach has been taken to identify the target genes that are regulated by these four LOLA splice variants. Future work will be done for the five other LOLA isoforms to categorize their putative DNA-binding sequences and subsequently their protein interactions.
Title: Identification of longitudinals lacking (LOLA) target genes in Drosophila melanogaster.
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Name(s): Qureshi, Bazila.
Charles E. Schmidt College of Science
Department of Biological Sciences
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Issued: 2010
Publisher: Florida Atlantic University
Physical Form: electronic
Extent: viii, 64 p. : ill. (some col.)
Language(s): English
Summary: Longitudinals lacking gene (LOLA) is a transcription factor that is involved in a variety of axon guidance decisions in Drosophila melanogaster nervous system. Besides having a role as an epigenetic silencer and in the programmed cell death in Drosophila's ovary, this gene is also an example of complex transcription unit. LOLA is a transcription repressor and can generate 17 DNA - binding isoforms, through alternative splicing, each containing distinct zinc-finger proteins. This unique DNAbinding binding sequence to which LOLA-ZFP binds has been determined for four of the lola isoforms F, J, P and K. Also, bioinformatics' tool approach has been taken to identify the target genes that are regulated by these four LOLA splice variants. Future work will be done for the five other LOLA isoforms to categorize their putative DNA-binding sequences and subsequently their protein interactions.
Identifier: 654098581 (oclc), 2684893 (digitool), FADT2684893 (IID), fau:3525 (fedora)
Note(s): by Bazila Qureshi.
Thesis (M.S.)--Florida Atlantic University, 2010.
Includes bibliography.
Electronic reproduction. Boca Raton, Fla., 2010. Mode of access: World Wide Web.
Subject(s): Transcription factors
Cellular signal transduction
Zinc-finger proteins -- Synthesis
Genetic transcription -- Regulation
Drosophila melanogaster -- Cytogenetics
Gene expression
Persistent Link to This Record: http://purl.flvc.org/FAU/2684893
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU