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Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina

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Date Issued:
1997
Summary:
The bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia, melanoma and nephrotoma. A series of experiments was undertaken to elucidate the biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme preparation and radiolabelled precursors. A regional characterization of Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also described.
Title: Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina.
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Name(s): Lawry, Joseph
Kerr, Russell G., Thesis advisor
Florida Atlantic University, Degree grantor
Charles E. Schmidt College of Science
Department of Chemistry and Biochemistry
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Created: 1997
Date Issued: 1997
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, FL
Physical Form: application/pdf
Extent: 98 p.
Language(s): English
Summary: The bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia, melanoma and nephrotoma. A series of experiments was undertaken to elucidate the biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme preparation and radiolabelled precursors. A regional characterization of Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also described.
Identifier: FA00000787 (IID)
Note(s): Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 1997.
Charles E. Schmidt College of Science
Subject(s): Macrolide antibiotics
Bryozoa
Marine pharmacology
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00000787
Sublocation: Digital Library
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Owner Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.