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Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge

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Date Issued:
1989
Title: Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
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Name(s): Burres, N. S.
Sazesh, S.
Gunawardana, G. P.
Clement, J. J.
Harbor Branch Oceanographic Institute
Type of Resource: text
Genre: Article
Date Issued: 1989
Publisher: American Association for Cancer Research.
Physical Form: pdf
Extent: 9 p.
Language(s): English
Identifier: FA00007199 (IID)
Note(s): A new cytotoxic acridine alkaloid that exhibited antitumor activity invivo was isolated from a marine Dercitus species sponge collected at adepth of 160 m in the Bahamas. This violet alkaloid, designated dercitin,inhibited the proliferation of cultured murine and human leukemia, lung,and colon tumor cells at nM concentrations (IC₅₀ values of 63-150 nM)and prolonged the life of mice bearing ascitic P388 tumors (%T/C=170,5 mg/kg, ip., QDI-9). Dercitin was also active against i.p. B16 melanomaand modestly inhibited the growth of s.c. Lewis lung carcinoma on thesame schedule. DNA blocked the antiproliferative effects of the agent inculture, and incorporation studies indicated that dercitin disrupted DNAand RNA synthesis with less effects on protein synthesis, similar to theeffects of known DNA intercalators.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 726
This manuscript is an author version with the final publication available and may be cited as: Burres, N. S., Sazesh, S., Gunawardana, G. P., & Clement, J. J. (1989). Antitumor activity and nucleic acid binding properties of Dercitin, a new acridine alkaloid isolated from a marine dercitus species sponge. Cancer Research, 49(19), 5267-5274.
Subject(s): Alkaloids
Acridines
Sponges
Antineoplastic agents
Cytotoxins
Marine natural products
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00007199
Owner Institution: FAU