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Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge
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|Title:||Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.||
Burres, N. S.
Gunawardana, G. P.
Clement, J. J.
Harbor Branch Oceanographic Institute
|Type of Resource:||text|
|Publisher:||American Association for Cancer Research.|
A new cytotoxic acridine alkaloid that exhibited antitumor activity invivo was isolated from a marine Dercitus species sponge collected at adepth of 160 m in the Bahamas. This violet alkaloid, designated dercitin,inhibited the proliferation of cultured murine and human leukemia, lung,and colon tumor cells at nM concentrations (IC₅₀ values of 63-150 nM)and prolonged the life of mice bearing ascitic P388 tumors (%T/C=170,5 mg/kg, ip., QDI-9). Dercitin was also active against i.p. B16 melanomaand modestly inhibited the growth of s.c. Lewis lung carcinoma on thesame schedule. DNA blocked the antiproliferative effects of the agent inculture, and incorporation studies indicated that dercitin disrupted DNAand RNA synthesis with less effects on protein synthesis, similar to theeffects of known DNA intercalators.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 726
This manuscript is an author version with the final publication available and may be cited as: Burres, N. S., Sazesh, S., Gunawardana, G. P., & Clement, J. J. (1989). Antitumor activity and nucleic acid binding properties of Dercitin, a new acridine alkaloid isolated from a marine dercitus species sponge. Cancer Research, 49(19), 5267-5274.
Marine natural products
|Persistent Link to This Record:||http://purl.flvc.org/fau/fd/FA00007199|