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Variation in the Major Histocompatibility Gene is Maintained By Selection Imposed By Infectious Disease.

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Date Issued:
2015
Summary:
Major Histocompatibility (MH) genes play critical roles in mounting adaptive immune responses to infectious diseases and parasites. There are two classes of MH genes: Class I and II; Class II can be further divided into Class II A and II B genes, this study focuses on Class IIB. Class II B genes are exceptionally variable in sequence. Leading hypotheses propose that this genetic variation is maintained by selection for resistance to pathogens. Since pathogens are constantly evolving to avoid detection, and new pathogens regularly enter populations, which MH proteins confer immunity fluctuates over time. This study examines MH Class II B in Centropomus undecimalis, the common Snook. Genes will be sequenced, and their variability quantified using approaches that include: database searches (NCBI), PCR, and sequencing. Sequencing of the MH gene will provide insight on how high polymorphism results from immune responses to infectious pathogens.
Title: Variation in the Major Histocompatibility Gene is Maintained By Selection Imposed By Infectious Disease.
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Name(s): Blair, Zizah J.
Hughes, Colin
Charles E. Schmidt College of Science
Type of Resource: text
Genre: Poster
Date Issued: 2015
Publisher: Florida Atlantic University Libraries: Digital Library
Physical Form: pdf
Extent: 1 p.
Language(s): English
Summary: Major Histocompatibility (MH) genes play critical roles in mounting adaptive immune responses to infectious diseases and parasites. There are two classes of MH genes: Class I and II; Class II can be further divided into Class II A and II B genes, this study focuses on Class IIB. Class II B genes are exceptionally variable in sequence. Leading hypotheses propose that this genetic variation is maintained by selection for resistance to pathogens. Since pathogens are constantly evolving to avoid detection, and new pathogens regularly enter populations, which MH proteins confer immunity fluctuates over time. This study examines MH Class II B in Centropomus undecimalis, the common Snook. Genes will be sequenced, and their variability quantified using approaches that include: database searches (NCBI), PCR, and sequencing. Sequencing of the MH gene will provide insight on how high polymorphism results from immune responses to infectious pathogens.
Identifier: FA00005177 (IID)
Subject(s): College students --Research --United States.
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00005177
Host Institution: FAU