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Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics
| Title: | Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics. |
 130 views 23 downloads |
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| Name(s): |
Nagase, Hideaki, creator Brew, Keith, creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 2002-04-02 | |
| Physical Form: | application/pdf | |
| Extent: | 12 p. | |
| Language(s): | English | |
| Summary: | Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs). This review highlights the structures and inhibition mechanism of TIMPs, the biological activities of TIMPs, the unique properties of TIMP-3, and the altered specificity towards MMPs achieved by mutagenesis. A potential therapeutic use of TIMP variants is discussed. | |
| Identifier: | 3327266 (digitool), FADT3327266 (IID), fau:1897 (fedora), 10.1186/ar573 (doi) | |
| College/Department: | Schmidt College of Medicine, Department of Biomedical Science | |
| Subject(s): |
Gene Therapy --Methods Genetic Engineering --methods Protein Structure, Tertiary Rheumatic Diseases --therapy Tissue Inhibitor of Metalloproteinases Wound Healing --physiology Metalloproteinases --Inhibitors --Therapeutic use |
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| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/3327266 | |
| Links: | https://doi.org/10.1186/ar573 | |
| Host Institution: | FAU |
