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Role of taurine in the central nervous system
| Title: | Role of taurine in the central nervous system. |
 141 views 38 downloads |
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| Name(s): |
Wu, Jang-Yen, creator Prentice, Howard, creator |
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| Type of Resource: | text | |
| Date Issued: | 2010-08-24 | |
| Physical Form: | application/pdf | |
| Extent: | 7 p. | |
| Language(s): | English | |
| Identifier: | 3327262 (digitool), FADT3327262 (IID), fau:1896 (fedora), 10.1186/1423-0127-17-S1-S1 (doi) | |
| Note(s): | Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating calcium transport and homeostasis, as an osmolyte, as a neuromodulator and as a neuroprotectant. The neurotransmitter properties of taurine are illustrated by its ability to elicit neuronal hyperpolarization, the presence of specific taurine synthesizing enzyme and receptors in the CNS and the presence of a taurine transporter system. Taurine exerts its neuroprotective functions against the glutamate induced excitotoxicity by reducing the glutamate-induced increase of intracellular calcium level, by shifting the ratio of Bcl-2 and Bad ratio in favor of cell survival and by reducing the ER stress. The presence of metabotropic taurine receptors which are negatively coupled to phospholipase C (PLC) signaling pathway through inhibitory G proteins is proposed, and the evidence supporting this notion is also presented. | |
| Subject(s): |
Central Nervous System --metabolism Glutamic Acid --metabolism Homeostasis --physiology Neuroprotective Agents --metabolism Neurotransmitter Agents --metabolism Proto-Oncogene Proteins c-bcl-2 --metabolism Receptors, Neurotransmitter --metabolism Signal Transduction --physiology Taurine Taurine --metabolism Neuroprotective Agents Neurotransmitter Agents |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FADT3327262 | |
| Host Institution: | FAU |
