You are here

analysis of the effectiveness of dichloroacetate as an anti-cancer agent

Download pdf | Full Screen View

Date Issued:
2010
Summary:
Dichloroacetate (DCA) is a chemical with potential to be a cancer therapy due to its ability to treat mitochondrial metabolic disorders. Previous studies have affirmed DCA's ability to target cancer cells, leaving healthy cells unharmed (Bonnet et al., 2007). Javonia Washington continued research that Bonnet et al. began by testing DCA's effectson a greater number of cell types (Washington, 2008). This project collects and analyzes the data generated by Washington's research using the computer programs Excel and SPSS. The analysis shows that DCA concentration is vital when considering the chemical as an anti-cancer drug ; it had a significant effect on the cancerous cells from 0.5mM and higher, but both cancerous and non-cancerous cells died at similar rates when the concentration reached 10mM. Further, DCA affects some cancer cells more quickly than others, which could increase the risk of harming surrounding healthy cells if used improperly as a cancer treatment.
Title: An analysis of the effectiveness of dichloroacetate as an anti-cancer agent.
149 views
38 downloads
Name(s): Flint, Valerie.
Harriet L. Wilkes Honors College
Type of Resource: text
Genre: Thesis
Issuance: multipart monograph
Date Issued: 2010
Publisher: Florida Atlantic University
Physical Form: electronic resource
Extent: viii, 17 p. : ill. (some col.)
Language(s): English
Summary: Dichloroacetate (DCA) is a chemical with potential to be a cancer therapy due to its ability to treat mitochondrial metabolic disorders. Previous studies have affirmed DCA's ability to target cancer cells, leaving healthy cells unharmed (Bonnet et al., 2007). Javonia Washington continued research that Bonnet et al. began by testing DCA's effectson a greater number of cell types (Washington, 2008). This project collects and analyzes the data generated by Washington's research using the computer programs Excel and SPSS. The analysis shows that DCA concentration is vital when considering the chemical as an anti-cancer drug ; it had a significant effect on the cancerous cells from 0.5mM and higher, but both cancerous and non-cancerous cells died at similar rates when the concentration reached 10mM. Further, DCA affects some cancer cells more quickly than others, which could increase the risk of harming surrounding healthy cells if used improperly as a cancer treatment.
Identifier: 779341732 (oclc), 3335018 (digitool), FADT3335018 (IID), fau:1398 (fedora)
Note(s): by Valerie Flint.
Thesis (B.A.)--Florida Atlantic University, Honors College, 2010.
Includes bibliography.
Electronic reproduction. Boca Raton, Fla., 2010. Mode of access: World Wide Web.
Subject(s): Chloroacetic acids -- Therapeutic use
Antineoplastic agents
Apoptosis
Held by: FBoU FAUER
Persistent Link to This Record: http://purl.flvc.org/FAU/3335018
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Host Institution: FAU

In Collections