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A novel method to evaluate local control of lung cancer in stereotactic body radiation therapy (SBRT) treatment using 18f-Fdg positron emission tomography (PET)

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Date Issued:
2013
Summary:
An improved method is introduced for prediction of local tumor control following lung stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) patients using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET). A normalized background-corrected tumor maximum Standard Uptake Value (SUVcmax) is introduced using the mean uptake of adjacent aorta (SUVref), instead of the maximum uptake of lung tumor (SUVmax). This method minimizes the variations associated with SUVmax and objectively demonstrates a strong correlation between the low SUVcmax (< 2.5-3.0) and local control of post lung SBRT. The false positive rates of both SUVmax and SUVcmax increase with inclusion of early (<6 months) PET scans, therefore such inclusion is not recommended for assessing local tumor control of post lung SBRT.
Title: A novel method to evaluate local control of lung cancer in stereotactic body radiation therapy (SBRT) treatment using 18f-Fdg positron emission tomography (PET).
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Name(s): Kathriarachchi, Vindu, author
Shang, Charles, Thesis advisor
Charles E. Schmidt College of Science, Degree grantor
Department of Physics
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: single unit
Date Created: Fall 2013
Date Issued: 2013
Publisher: Florida Atlantic University
Physical Form: Online Resource
Extent: 81 p.
Language(s): English
Summary: An improved method is introduced for prediction of local tumor control following lung stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) patients using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET). A normalized background-corrected tumor maximum Standard Uptake Value (SUVcmax) is introduced using the mean uptake of adjacent aorta (SUVref), instead of the maximum uptake of lung tumor (SUVmax). This method minimizes the variations associated with SUVmax and objectively demonstrates a strong correlation between the low SUVcmax (< 2.5-3.0) and local control of post lung SBRT. The false positive rates of both SUVmax and SUVcmax increase with inclusion of early (<6 months) PET scans, therefore such inclusion is not recommended for assessing local tumor control of post lung SBRT.
Identifier: FA0004029 (IID)
Note(s): Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2013.
Subject(s): Cancer -- Radiotherapy
Image guided radiation therapy
Lung cancer -- Treatment
Radiopharmaceuticals
Tomography, Emission
Held by: Florida Atlantic University Digital Library
Sublocation: Boca Raton, Fla.
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA0004029
Restrictions on Access: All rights reserved by the source institution
Restrictions on Access: http://rightsstatements.org/vocab/InC/1.0/
Owner Institution: FAU