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efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis

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Date Issued:
1999
Summary:
The ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate using oxidative deamination of cysteine by amino acid oxidase.
Title: An efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis.
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Name(s): Fawehinmi, Hafusat Abosede
Florida Atlantic University, Degree Grantor
Kerr, Russell G., Thesis Advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1999
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 66 p.
Language(s): English
Summary: The ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate using oxidative deamination of cysteine by amino acid oxidase.
Identifier: 9780599540545 (isbn), 15725 (digitool), FADT15725 (IID), fau:12481 (fedora)
Note(s): Thesis (M.S.)--Florida Atlantic University, 1999.
Subject(s): Tunicata
Pyruvic acid--Synthesis
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/15725
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
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Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.