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Adult preference for morphine can be predicted from infant loss-of-righting response

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Date Issued:
1988
Summary:
Infant rats display differences in duration of loss-of-righting (LOR) in response to an hypnotic dose of morphine sulfate. These differences in LOR duration are predictive of the rats' preference for drinking morphine solutions as adults. Infants tested at 16 days of age were designated Short-, Medium-, or Long-sleep based upon a 2.5 mg/kg dose of morphine sulfate administered intraperitoneally. Infants displaying long durations of LOR (long-sleep) subsequently display a marked preference for morphine solutions when tested as adults. Conversely, infants that displayed little or no LOR (short-sleep) did not consume as much of the morphine solutions in subsequent testing. This effect was consistent across the animals tested and appears to be independent of the screening dose. These findings demonstrate that adult differences in preference for drinking morphine solutions can be predicted in infancy.
Title: Adult preference for morphine can be predicted from infant loss-of-righting response.
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Name(s): Siegel, Lawrence Allen.
Florida Atlantic University, Degree grantor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1988
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 73 p.
Language(s): English
Summary: Infant rats display differences in duration of loss-of-righting (LOR) in response to an hypnotic dose of morphine sulfate. These differences in LOR duration are predictive of the rats' preference for drinking morphine solutions as adults. Infants tested at 16 days of age were designated Short-, Medium-, or Long-sleep based upon a 2.5 mg/kg dose of morphine sulfate administered intraperitoneally. Infants displaying long durations of LOR (long-sleep) subsequently display a marked preference for morphine solutions when tested as adults. Conversely, infants that displayed little or no LOR (short-sleep) did not consume as much of the morphine solutions in subsequent testing. This effect was consistent across the animals tested and appears to be independent of the screening dose. These findings demonstrate that adult differences in preference for drinking morphine solutions can be predicted in infancy.
Identifier: 14492 (digitool), FADT14492 (IID), fau:11290 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Thesis (M.A.)--Florida Atlantic University, 1988.
Charles E. Schmidt College of Science
Subject(s): Conditioned response
Morphine
Narcotics
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14492
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.