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EFFECTIVENESS OF ANTI-HERPETIC COMPOUNDS ON PACHECO'S DISEASE VIRUS OF PSITTACINES
| Title: | EFFECTIVENESS OF ANTI-HERPETIC COMPOUNDS ON PACHECO'S DISEASE VIRUS OF PSITTACINES. |
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| Name(s): |
AVERY, PATRICIA OTTENS. Florida Atlantic University, Degree grantor Hartmann, James X., Thesis advisor |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Issuance: | monographic | |
| Date Issued: | 1983 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 89 p. | |
| Language(s): | English | |
| Summary: | Three antiviral compounds, 5-iodo-2' -deoxyuridine (IUDR), 9-(2-hydroxyethoxymethyl )guanine (acyclovir) and methylglyoxal-bis-(guanylhydrazone) MGBG were tested for their effectiveness against Pacheco's disease virus (PDV). IUDR caused a fifty percent reduction in plaque formation (PR50) at 0 .8 μM in chicken embryo fibroblasts while acyclovir showed a PR50 of 6.6 μM. Plaque inhibition assays showed a significant decrease in plaque size (1.25 mm to 0.45 mm) at 10 μM acyclovir and (1.3 mm to 0.5 mm) at both 1 μM and 10 μM of IUDR. MGBG did not reduce virus replication vitro, and an apparent reduction of virus growth in vivo was probably due to toxicity. However, in vitro toxicity studies did not show any significant reduction in cell growth with any of the compounds tested. | |
| Identifier: | 14145 (digitool), FADT14145 (IID), fau:10958 (fedora) | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): |
Thesis (M.S.)--Florida Atlantic University, 1983. Charles E. Schmidt College of Science |
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| Subject(s): |
Herpesviruses Birds--Diseases Psittacosis |
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| Held by: | Florida Atlantic University Libraries | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/14145 | |
| Sublocation: | Digital Library | |
| Use and Reproduction: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
