You are here

FAU Collections » FAU Research Repository » FAU Theses and Dissertations

study on glucose metabolism: Computer simulation and modeling

Download pdf | Full Screen View

Date Issued:
2005
Summary:
Sorensen's model of glucose metabolism and regulation is reconstructed using SimulinkRTM. Most of the existing glucose metabolism models consist of several mass balance equations that interact with each others. Graphical format used by SimulinkRTM provides a visualized perspective of such relations so that it is easier to modify the model on ad hoc basis. Type-I and Type-II diabetes with relevant clinical details are simulated. Further, a control strategy is introduced in order to simulate the control of exogenous insulin pump. Simulated results are consistent with available clinical data. Living systems in general, exhibit both stochastical and deterministic characteristics. Activities such as glucose metabolism traditionally modeled do not include stochastical properties, nor that they are viewed in the large framework of complex system with explicit interaction details. Currently, a complexity system model is developed to describe the glucose metabolism related activities. The simulation results obtained thereof illustrate the bounding domain of variations in some clinically observed details.
Title: A study on glucose metabolism: Computer simulation and modeling.
104 views
53 downloads
Name(s): Leesirikul, Meta.
Florida Atlantic University, Degree grantor
Neelakanta, Perambur S., Thesis advisor
Roth, Zvi S., Thesis advisor
Morgera, Salvatore D., Thesis advisor
College of Engineering and Computer Science
Department of Computer and Electrical Engineering and Computer Science
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 2005
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 161 p.
Language(s): English
Summary: Sorensen's model of glucose metabolism and regulation is reconstructed using SimulinkRTM. Most of the existing glucose metabolism models consist of several mass balance equations that interact with each others. Graphical format used by SimulinkRTM provides a visualized perspective of such relations so that it is easier to modify the model on ad hoc basis. Type-I and Type-II diabetes with relevant clinical details are simulated. Further, a control strategy is introduced in order to simulate the control of exogenous insulin pump. Simulated results are consistent with available clinical data. Living systems in general, exhibit both stochastical and deterministic characteristics. Activities such as glucose metabolism traditionally modeled do not include stochastical properties, nor that they are viewed in the large framework of complex system with explicit interaction details. Currently, a complexity system model is developed to describe the glucose metabolism related activities. The simulation results obtained thereof illustrate the bounding domain of variations in some clinically observed details.
Identifier: 9780542137648 (isbn), 13254 (digitool), FADT13254 (IID), fau:10109 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): College of Engineering and Computer Science
Thesis (M.S.)--Florida Atlantic University, 2005.
Subject(s): Glucose--Metabolism
Computer simulation
Diabetes--Metabolism
Computer modeling
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/13254
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.